Sue Ok Yu

Apr 20, 2024 | biorxiv.org | Ronald Brown |Richard Lang |Brannen Dyer |Sue Ok Yu

AbstractIntrinsically photosensitive retinal ganglion cells (ipRGCs) play a crucial role in several physiological light responses. In this study we generate a new Opn4cre knock-in allele (Opn4cre(DSO)), in which cre is placed immediately downstream of the Opn4 start codon. This approach aims to faithfully reproduce endogenous Opn4 expression and improve compatibility with widely used reporters.