Suneil K. Kalia

Jan 29, 2025 | cell.com | Lorraine V. Kalia |Suneil K. Kalia

Jul 12, 2024 | nature.com | Suneil K. Kalia

AbstractAccumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson’s disease (PD). High frequency electrical stimulation (HFS) mimicking clinical parameters used for deep brain stimulation (DBS) in vitro or DBS in vivo in preclinical models of PD have been found to reduce levels of α-Syn and, in certain cases, provide possible neuroprotection.

May 27, 2024 | mdpi.com | Ying Meng |Lorraine V. Kalia |Suneil K. Kalia |Clement Hamani

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Dec 10, 2023 | biorxiv.org | Yupeng Tian |David Crompton |Suneil K. Kalia |Edward Bello

AbstractThalamic ventral intermediate nucleus (Vim) is the primary surgical target of deep brain stimulation (DBS) for reducing symptoms of essential tremor. In-vivo single unit recordings of patients with essential tremor revealed that low frequency Vim-DBS (≤50Hz) induces periodic excitatory responses and high-frequency Vim-DBS (≥100Hz) induces a transient excitatory response lasting for ≤600ms followed by a suppressed steady-state.