Surabhi Abhyankar

1 month ago | biorxiv.org | Surabhi Abhyankar |Yucheng Xiao |Neha Mahajan |Qianyi Luo

AbstractAlzheimer's disease (AD), particularly late-onset AD (LOAD), affects millions worldwide, with the apolipoprotein E4 (APOE4) allele being a significant genetic risk factor. Retinal abnormalities are a hallmark of LOAD, and our recent study demonstrated significant age-related retinal impairments in APOE4-knock-in (KI) mice, highlighting that retinal impairments occur before the onset of cognitive decline in these mice.