Susan Allison

1 week ago | nature.com | Susan Allison

The administration of anti-inflammatory macrophages has been proposed as an approach to reduce tissue injury in response to inflammation; however, this approach is limited by the instability of macrophages and their potential to switch to a pro-inflammatory phenotype. To overcome these limitations, researchers have now developed a chimeric antigen receptor (CAR) macrophage (CAR-M) that demonstrates anti-inflammatory functions in response to a pro-inflammatory stimulus.

1 month ago | nature.com | Susan Allison

IgA nephropathy (IgAN) is a common form of glomerulonephritis. Its pathogenesis has been linked to aberrant O-glycosylation of the IgA1 hinge region, which is thought to underlie the formation of IgA1-containing immune complexes that deposit in glomeruli. New insights suggest that IgA O-glycosylation may also affect additional processes, including mucosal immunity and B cell homing to mucosal and non-mucosal lymphoid tissues.

2 months ago | nature.com | Susan Allison

African American kidney transplant recipients exhibit a higher risk of graft failure than other racial and ethnic groups even after accounting for HLA mismatches and socioeconomic status, which suggests a role for other risk factors.

Feb 25, 2025 | nature.com | Susan Allison

Despite the emergence of immune-based therapies, patients who undergo nephrectomy for clear cell renal cell carcinoma (ccRCC) remain at high risk of cancer recurrence, highlighting an unmet clinical need to improve outcomes for these patients. Personalized cancer vaccines (PCVs) aimed at neoantigens derived from tumour-specific mutations have demonstrated benefits in patients with tumours having high mutational burdens, such as melanoma.

Jan 28, 2025 | nature.com | Susan Allison

Chronic kidney disease of undetermined cause (CKDu) is a progressive form of chronic kidney disease (CKD) that is not associated with common risk factors for CKD and mainly affects adults in low- and middle-income countries (LMICs). Researchers from the disadvantaged populations estimated glomerular filtration rate (eGFR) epidemiology (DEGREE) study now report initial insights into the burden of CKDu globally.