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3 days ago | 
nature.com | Susan Allison
IgA nephropathy (IgAN) is a common form of glomerulonephritis. Its pathogenesis has been linked to aberrant O-glycosylation of the IgA1 hinge region, which is thought to underlie the formation of IgA1-containing immune complexes that deposit in glomeruli. New insights suggest that IgA O-glycosylation may also affect additional processes, including mucosal immunity and B cell homing to mucosal and non-mucosal lymphoid tissues.
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3 weeks ago | 
nature.com | Susan Allison
African American kidney transplant recipients exhibit a higher risk of graft failure than other racial and ethnic groups even after accounting for HLA mismatches and socioeconomic status, which suggests a role for other risk factors.
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1 month ago | 
nature.com | Susan Allison
Despite the emergence of immune-based therapies, patients who undergo nephrectomy for clear cell renal cell carcinoma (ccRCC) remain at high risk of cancer recurrence, highlighting an unmet clinical need to improve outcomes for these patients. Personalized cancer vaccines (PCVs) aimed at neoantigens derived from tumour-specific mutations have demonstrated benefits in patients with tumours having high mutational burdens, such as melanoma.
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2 months ago | 
nature.com | Susan Allison
Chronic kidney disease of undetermined cause (CKDu) is a progressive form of chronic kidney disease (CKD) that is not associated with common risk factors for CKD and mainly affects adults in low- and middle-income countries (LMICs). Researchers from the disadvantaged populations estimated glomerular filtration rate (eGFR) epidemiology (DEGREE) study now report initial insights into the burden of CKDu globally.
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Nov 26, 2024 | 
nature.com | Susan Allison
The G1 and G2 APOL1 risk alleles are important risk factors for chronic kidney disease (CKD) among Black Americans; however, the genetic risk of CKD associated with APOL1 variants among individuals living in West Africa — the ancestral origin of most Black Americans — has not been thoroughly investigated.
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Nov 26, 2024 | 
nature.com | Susan Allison
Recognition that allograft microvascular inflammation can occur in the absence of circulating donor-specific anti-HLA antibodies (DSAs) led to the inclusion of two new categories in the diagnostic framework of the 2022 Banff Classification of Renal Allograft Pathology: ‘microvascular inflammation or injury (MVI), DSA-negative, and C4d-negative’, which includes cases of allograft rejection with no evidence of an antibody-mediated response; and ‘probable antibody-mediated rejection’, which...
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Oct 30, 2024 | 
nature.com | Susan Allison
Fibrosis results from the continuous deposition of extracellular matrix (ECM) by fibroblasts in response to injurious stimuli; however, the exact roles of fibroblasts in this process are unclear. New findings demonstrate a key role for the protease ADAMTS12 in driving fibrosis through the remodelling of ECM and activation of profibrotic fibroblasts.
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Sep 25, 2024 | 
nature.com | Susan Allison
Improved understanding of the cellular changes and interactions that occur in the kidney following injury may help to elucidate the mechanisms that govern the transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and aid the development of therapeutic interventions.
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Sep 25, 2024 | 
nature.com | Susan Allison
Monogenic alterations cause a variety of paediatric kidney diseases; however, insights into their association with clinical outcomes are limited. New analyses of three cohorts demonstrate that monogenic kidney disorders are associated with an increased risk of kidney failure. “These data suggest that recognition of genetic kidney disorders will be important for clinical evaluation, understanding prognosis, and counselling for patients,” say the researchers.
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Aug 27, 2024 | 
nature.com | Susan Allison
Cognitive decline is common in patients with chronic kidney disease (CKD); however, the mechanisms linking these two conditions is unclear. New research suggests that disruption of the blood–brain barrier (BBB) by uraemic toxins may lead to microglial activation and subsequent IL-1 receptor (IL-1R)-mediated neuronal impairment.
