Susan H. Wootton

Jul 22, 2024 | digitalcommons.library.tmc.edu | Joyce P. Samuel |Susan H. Wootton |Jon E. Tyson

Observational studies are notoriously susceptible to bias, and parallel-group randomized trials are important to identify the best overall treatment for eligible patients. Yet, such trials can be expected to be a misleading indicator of the best treatment for some subgroups or individual patients. In selected circumstances, patients can be treated in n-of-1 trials to address the inherent heterogeneity of treatment response in clinical populations.

Jul 22, 2024 | digitalcommons.library.tmc.edu | Joyce P. Samuel |Susan H. Wootton

AbstractThe ethical and regulatory oversight of any clinical activity related to human subjects is commonly determined based on its categorization as either clinical practice or research. Prominent bioethicists have criticized the traditional distinctions used to delineate these categories, calling them counterproductive and outmoded, and arguing that learning and clinical practice should be deliberately and appropriately integrated.

Feb 22, 2024 | onlinelibrary.wiley.com | Susan H. Wootton |Matthew A. Rysavy |Peter Davis |Newborn Research

Corresponding Author Susan H. Wootton Division of Infectious Diseases, Department of Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA Institute for Clinical Research and Learning Health Care, McGovern Medical School at UTHealth Houston, Houston, Texas, USA Children's Memorial Hermann Hospital, Houston, Texas, USA Correspondence Susan H.