Sutanu Nandi

1 month ago | biorxiv.org | Hamda B Ajmal |Sutanu Nandi |Narod Kebabci |Colm A. Ryan

AbstractSynthetic lethality (SL) is an extreme form of negative genetic interaction, where simultaneous disruption of two non-essential genes causes cell death. SL can be exploited to develop cancer therapies that target tumour cells with specific mutations, potentially limiting toxicity. Pooled combinatorial CRISPR screens, where two genes are simultaneously perturbed and the resulting impacts on fitness estimated, are now widely used for the identification of SL targets in cancer.