Sylvain Tranchimand

Nov 3, 2024 | biorxiv.org | Sylvain Tranchimand |Patricia Leroyer |Jean-Paul Chapel |Manon Rochedy

AbstractThe development of natural or synthetic polycations able to interact with nucleic acids and condense them into nanoparticles known as polyplexes, faces several unresolved challenges at the cellular level. Key issues include the intracellular trafficking of polyplexes, the endosomal escape and the release of nucleic acids into the cytosol, which are considered major bottlenecks for efficient protein expression.