Sylvia Whittle

Sep 7, 2024 | biorxiv.org | Indresh Yadav |Elizabeth Holmes |Bradley Diggines |Sylvia Whittle

AbstractKinetoplast DNA is a complex nanoscale network, naturally assembled from thousands of interconnected DNA circles within the mitochondrion of certain parasites. Despite the relevance of this molecule to parasitology and the recent discovery of tuneable mechanics, its topology remains highly contested. Here we present a multiscale analysis into the structure of kDNA using a combination of high-resolution atomic force microscopy and custom-designed image analysis protocols.

Apr 30, 2024 | pubs.rsc.org | Bradley Diggines |Sylvia Whittle |Indresh Yadav |Elizabeth Holmes

Multiscale topological analysis of kinetoplast DNA via high resolution AFM Kinetoplast DNA is a complex nanoscale network, naturally assembled from thousands of interconnected DNA circles within the mitochondrion of certain parasites. Despite the relevance of this molecule to parasitology and the recent discovery of tuneable mechanics, its topology remains highly contested.