Tadashi Yamamuro

Aug 22, 2024 | nature.com | Maho Hamasaki |Tadashi Yamamuro |Tatsuya Kaminishi |Satoshi Oikawa |Yoko Tanaka |Keisuke Tabata | +4 more

AbstractCells release intraluminal vesicles in multivesicular bodies as exosomes to communicate with other cells. Although recent studies suggest an intimate link between exosome biogenesis and autophagy, the detailed mechanism is not fully understood. Here we employed comprehensive RNA interference screening for autophagy-related factors and discovered that Rubicon, a negative regulator of autophagy, is essential for exosome release.