Tae Sung

2 months ago | cell.com | Cynthia Palmer |Britton Boras |Scott Garza |Jing Yuan |Tae Sung |Elizabeth McMillan | +45 more

KeywordsatirmociclibPF-07220060CDK4cyclin D1breast cancercell cyclecell cycle inhibitorneutropeniacyclin-dependent kinaseCDK6IntroductionAberrant cell proliferation is a fundamental hallmark of human cancer.1 In tumor cells, it is frequently orchestrated by cyclin D-dependent kinases, CDK4 and CDK6; each kinase forms active complexes with one of the three D-type cyclins (D1, D2, or D3).