Taibo Li

Jul 13, 2023 | nature.com | Jacob C. Ulirsch |Masahiro Kanai |Francois Aguet |Taibo Li |Aviv Regev |Jesse M. Engreitz

AbstractGenome-wide association studies (GWASs) are a valuable tool for understanding the biology of complex human traits and diseases, but associated variants rarely point directly to causal genes. In the present study, we introduce a new method, polygenic priority score (PoPS), that learns trait-relevant gene features, such as cell-type-specific expression, to prioritize genes at GWAS loci.