Taitu Lin

3 weeks ago | biorxiv.org | Qingqing Shen |Wang Cao |Ming Zhang |Taitu Lin

AbstractAccurately measuring circulating proinsulin proteoforms is crucial for clinical investigation of diabetes, but was previously not feasible owing to limited assay specificity/sensitivity. Here we devised a highly sensitive LC-MS-based strategy to quantify intact proinsulin, des-31,32 and des-64,65 proinsulin, and C-peptide in circulation.