Tamara G. Amstislavskaya

Oct 23, 2024 | jneurosci.org | Tatiana Lipina |Tamara G. Amstislavskaya |Ryan Cameron |Christina Elliott

Ethical approvalsMouse experiments were approved by The Centre for Phenogenomics (TCP) Animal Care Committee and were conducted in compliance with the Ontario Animals for Research Act 1971 and Canadian Council on Animal Care guidelines.

Sep 4, 2024 | jneurosci.org | Tatiana Lipina |Tamara G. Amstislavskaya |Ryan Cameron |Christina Elliott

AbstractLarge-scale genome-wide association studies (GWAS) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood.