Tanja Habeck

May 14, 2024 | nature.com | Tanja Habeck |Kyle Brown |Mowei Zhou |Michael Volný |Jeffrey N. Agar |Ying Ge | +4 more

AbstractThe combination of native electrospray ionization with top-down fragmentation in mass spectrometry (MS) allows simultaneous determination of the stoichiometry of noncovalent complexes and identification of their component proteoforms and cofactors. Although this approach is powerful, both native MS and top-down MS are not yet well standardized, and only a limited number of laboratories regularly carry out this type of research.