Tanujit Dey

Nov 12, 2024 | nature.com | Mengyuan Ruan |Tanujit Dey |Youn Jung |Leila J. Mady |Sophie Yu |John Cramer | +6 more

To investigate air pollution’s effect in the form of PM2.5 (particulate matter measuring less than 2.5 microns) on head and neck aerodigestive cancer incidence, an epidemiological cohort analysis was performed using data from the Surveillance Epidemiology and End Results national cancer database from the years 2002–2012. The relationship between US county mean PM2.5 levels and head and neck cancer (HNC) incidence rates were examined using a linear mixed model. Lagged effect of the pollutant’s effect on HNC incidence was analyzed. Our results showed a significant association between the incidence of HNC and certain subtypes with PM2.5 exposure after controlling for demographic characteristics, smoking and alcohol use. We observed the highest association at a 5-year lag period (β = 0.24, p value < 0.001). We observed significant associations at no lag (β = 0.16, p value = 0.02) and up to a 20-year lag period (β = 0.15, p value < 0.001). PM2.5 exposure is associated with an increased incidence of HNC, with the strongest association at a 5-year lag period. To better understand the relationships between exposure and cancer pathogenesis, further subgroup analysis is needed.

Oct 24, 2024 | jamanetwork.com | Christina A. Minami |Tanujit Dey |Yu-Jen Chen |Rachel A. Freedman

Key PointsQuestion  To what extent does health service area contribute to variation in deescalated care in older adults with early-stage hormone receptor–positive breast cancer? Findings  In this cohort study with 9173 patients, most variation (61.8%) was attributed to random or unexplained factors. Measured factors, such as health service area (35.3%) and patient factors (2.8%), explained a minority of the variation.

Jun 7, 2024 | mdpi.com | Sounak Chakraborty |Tanujit Dey |Lingwei Xiang |Joel T. Adler

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Apr 6, 2024 | onlinelibrary.wiley.com | Hao Xue |Sounak Chakraborty |Tanujit Dey

Supporting Information Filename Description sam11682-sup-0001-Supinfo.pdfPDF document, 270.7 KB Data S1. Details of simulation models, posterior derivations, and extension to binary outcomes 2–5. REFERENCES 1, , and , Expanding role of pi5p4ks in cancer: A promising druggable target, FEBS Lett. 596 (2022), no. 1, 3–16. 2, , , , , , and , Bayesian factor regression models in the “large p, small n” paradigm, Bayesian Stat. 7 (2003), 733–742.

Aug 28, 2023 | jamanetwork.com | H. Gilbert Welch |Tanujit Dey

Testing Whether Cancer Screening Saves Lives: Implications for Randomized Clinical Trials of Multicancer Screening Lifetime Gained With Cancer Screening—Reply Michael Bretthauer, MD, PhD; Michal F. Kaminski, MD, PhD; Mette Kalager, MD, PhD Lifetime Gained With Cancer Screening Hermann Brenner, MD, MPH; Michael Hoffmeister, PhD Lifetime Gained With Cancer Screening Ernst J. Kuipers, MD, PhD; Manon C. W.