Taojun He

Nov 14, 2024 | ard.bmj.com | Hui Wu |Hanmei Yuan |Jin Zhang |Taojun He

Arthritis, RheumatoidAnti-Citrullinated Protein AntibodiesAntibodiesData availability statementData are available on reasonable request.

Oct 30, 2024 | prod--journal.elifesciences.org | Jin Zhang |Taojun He |Hanmei Yuan |Hui Wu

eLife Assessment This important study provides interesting insights into the mechanisms of action of adjuvants. It shows that adjuvants, MPLA and CpG especially, modulate the peptide repertoires presented on the surface of antigen presenting cells, and surprisingly, adjuvant favored the presentation of low-stability peptides rather than high-stability peptides by antigen presenting cells. As a result, the low stability peptide presented in adjuvant groups elicits T cell response effectively.

Aug 17, 2024 | biorxiv.org | Jin Zhang |Taojun He |Hanmei Yuan |Hui Wu

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Aug 6, 2024 | ard.bmj.com | Hui Wu |Hanmei Yuan |Jin Zhang |Taojun He

DiscussionRA is among the most common chronic inflammatory diseases, affecting around 1% of the global population.1 H. pylori, a prevalent bacteria in humans, has been intensively studied over the past three decades to identify the characteristics responsible for instigating host immunity that results in some autoimmune diseases.32–34 In this study, we demonstrated that disease activity and ACPA levels were significantly higher in H. pylori-infected patients with RA than in H.

May 21, 2024 | biorxiv.org | Jin Zhang |Taojun He |Hanmei Yuan |Hui Wu

AbstractAdjuvants can affect the function of APCs and boost the adaptive immune responses post vaccination. However, whether adjuvants modulate the specificity of immune responses, especially the specificity of immunodominant epitope responses, and the mechanisms of adjuvants regulating antigen processing and presentation remain poorly defined.