Tara TeSlaa

Mar 17, 2024 | nature.com | Tara TeSlaa

The mechanism by which metformin affects food intake remains controversial. Now, two studies link metformin treatment with the induction of the appetite-suppressing metabolite N-lactoyl-phenylalanine, which is produced by the intestine.

Jan 2, 2024 | cell.com | Matthew McBride |Craig Hunter |Zhaoyue Zhang |Tara TeSlaa

Gao X. Lee K. Reid M.A. Sanderson S.M. Qiu C. Li S. Liu J. Locasale J.W. Serine availability influences mitochondrial dynamics and function through lipid metabolism. Cell Rep. 2018; 22: 3507-3520Amino acid homeostasis and signalling in mammalian cells and organisms. Biochem. J. 2017; 474: 1935-1963Gaggini M. Carli F. Rosso C. Buzzigoli E. Marietti M. Della Latta V. Ciociaro D. Abate M.L. Gambino R. Cassader M. et al. Altered amino acid concentrations in NAFLD: impact of obesity and insulin resistance. Hepatology.

Aug 23, 2023 | nature.com | Tara TeSlaa |Markus Ralser |Jing Fan

AbstractThe pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). Ribose 5-phosphate is used for nucleotide synthesis, while NADPH is involved in redox homoeostasis as well as in promoting biosynthetic processes, such as the synthesis of tetrahydrofolate, deoxyribonucleotides, proline, fatty acids and cholesterol.