Tatsuya Akutsu

Aug 11, 2024 | nature.com | Tatsuya Akutsu |Jean-Marc Schwartz

AbstractNetwork controllability is unifying the traditional control theory with the structural network information rooted in many large-scale biological systems of interest, from intracellular networks in molecular biology to brain neuronal networks. In controllability approaches, the set of minimum driver nodes is not unique, and critical nodes are the most important control elements because they appear in all possible solution sets.

Jan 19, 2024 | nature.com | Tatsuya Akutsu |Jean-Marc Schwartz |Wataru Someya

AbstractRecent controllability analyses have demonstrated that driver nodes tend to be associated to genes related to important biological functions as well as human diseases. While researchers have focused on identifying critical nodes, intermittent nodes have received much less attention. Here, we propose a new efficient algorithm based on the Hamming distance for computing the importance of intermittent nodes using a Minimum Dominating Set (MDS)-based control model.