Taymin du Toit-Thompson

Mar 4, 2024 | onlinelibrary.wiley.com | Sooin Byeon |Taymin du Toit-Thompson |Luke Hipperson |Sarah Maloney

1 INTRODUCTION Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and has one of the worst prognostic outcomes (~9% 5-year survival) among all major solid tumors.1 In fact, it is projected to become the second leading cause of cancer-related deaths by 2030.2 The late-stage diagnosis of PDAC is attributable to dismal survival outcomes, as a majority of patients have advanced, unresectable disease at diagnosis.

Aug 3, 2023 | onlinelibrary.wiley.com | Sooin Byeon |Anthony Gill |Taymin du Toit-Thompson |Josef Gillson

3.2 Coexistence of different genotypes within classical biopsy-derived pancreatic cancer organoids Although bulk RNA-sequencing has enabled genotypic classifications of PDAC tumors, this approach may not be adequate to delineate heterogeneous cellular subpopulations in PDAC TME, with growing evidence that more than one genotypic characteristic can be portrayed by different cell types at the single-cell level within a tumor.