Teresa Esch

RT @Timothy0Leary: We locked ~100 neuroscientists in a building somewhere near the Potomac river and asked them what they thought about Rep…

This Week in the Journal @SfNJournals is my last of ~720 installments, highlighting >2100 articles. I've learned lots! I won't be going away though:I'll still edit Journal Clubs & other features for JN, plus do some other freelance editing & writing https://t.co/nhNIoZ1T5b https://t.co/k059C59jOm

RT @SteveStuWill: This optical illusion – one of the best of the last few years – will really mess with your head. How many black dots are…

The kinase DLK, activated by neuronal injury, initiates signaling that results in regeneration or apoptosis. Corticospinal axons usually don't regrow, but they can be made to do; This Week @SfNJournals Saikia &al show DLK contributes to this regeneration. https://t.co/nhTWWPXks5 https://t.co/b3CUsTdFVk

There are ongoing debates about how many synaptic pools are in presynaptic terminals & which vesicles contribute to spontaneous release. This Week @SfNJournals Egashira &al argue that spontaneously released vesicles come from the readily releasable pool. https://t.co/TeVztJpVm9 https://t.co/2B5MbmNhUq

Light responses initiated by rhodopsin are terminated by phosphorylation & arrestin1 binding. For >20 years arrestin1 was thought to inhibit rhodopsin dephosphorylation & recycling. But This Week @SfNJournals Hsieh &al show the opposite effect in vivo. https://t.co/TeVztJpVm9 https://t.co/BnDTTI7WGt

The complement system attracts macrophages to injury sites to clear debris & pathogens. A Journal Club @SfNJournals by @JenknerSandra & @DrRyanDoig describes work by Peterson, @stevens1lab &al showing the importance of complement in optic nerve regrowth. https://t.co/EKt14mN2Xm https://t.co/RgNQ6uMI3B

Entorhinal input to distal dendrites of CA1 pyramidal cells need help to influence neuronal output. This Week @SfNJournals, Bock &al show that mild somatic depolarization increases odds that distally generated dendritic spikes will induce somatic spiking. https://t.co/7IFqkUSPWN https://t.co/P7xbbwF50d

The internal capsule contains corticofugal, thalamocortical & striatonigral axons. This Week @SfNJournals, Ehrman &al show that striatonigral axons pioneer the internal capsule and guide later-growing corticofugal axons thru this structure to the midbrain. https://t.co/7IFqkUSPWN https://t.co/rIwwp5YtDo

Do adolescent rats value rewards they get for nothing more than rewards they have to work for? Find out in a Journal Club @SfNJournals by Brandon Toth discussing work by @Dr_Bediya, @bita137 &al. https://t.co/yozf91Lal1 https://t.co/6rt5zaC7Ht

Dysfunction of NMDA receptors in prefrontal cortical inhibitory neurons is tied to psychosis. This week @SfNJournals, Yao &al show that activation of extrasynaptic NMDA receptors on these neurons increases their excitability and spontaneous spike rate. https://t.co/Gukh7d5gUx https://t.co/CovocUez4R

Antibodies against NMDA receptors produced by certain peripheral tumors can enter the brain. This Week @SfNJournals, @AndrzejakEwa &al show such antibodies selectively target inhibitory neurons in cortex, which may explain patients' psychotic symptoms. https://t.co/Gukh7d5gUx https://t.co/IDoRs2iPO2

Dentate granule cell activity is regulated by reciprocal connections w/hilar mossy cells. What controls mossy cell spiking is unclear, but This Week @SfNJournals @czarinaramos_ &al show that extrasynaptic, but not synaptic kainate receptors play a role. https://t.co/teszmlZyjX https://t.co/0LGExMMyKC

Extracellular structures called perineuronal nets form around inhibitory interneurons & regulate cortical plasticity. This Week @SfNJournals Mascio &al show formation of these nets occurs with inflammatory pain & removing them relieves pain in mice. https://t.co/teszmlZyjX https://t.co/SbWK8P1gjy

Neurons are often distinguished by their selective expression of calcium binding proteins. What are the specific benefits of these proteins? @RuiliXie &al show @SfNJournals that calretinin helps a subset of auditory fibers maintain high-frequency spiking. https://t.co/E19P5e8rEx https://t.co/E2Smph86OS

Balanced activity in two populations of striatal neurons is required for normal motor function. This Week @SfNJournals, @NelsonLabUCSF &al show that caffeine-induced silencing of one population—indirect pathway neurons—underlies a rare form of dyskinesia. https://t.co/E19P5e8rEx https://t.co/z1f25EwAtu

If an object causes pain even once, we remember the event & are cautious later. In a Journal Club @SfNJournals , @__GeorgiaTurner & @onyskj discuss work by @gelliott_wimmer & @C_Buchel showing the role of the hippocampus in such one-trial learning. https://t.co/VDS2ZQheWB https://t.co/Tn8ztp3r0f