Tessandra Stewart

Oct 5, 2023 | movementdisorders.onlinelibrary.wiley.com | Ying Yang |Tessandra Stewart |Can Zhang |Pan Wang

Introduction Transmission of pathological α-synuclein (α-syn) plays a key role in the progression of Parkinson's disease (PD), and it has been demonstrated that extracellular vesicles (EVs), small membrane-bound vesicles that transport cargos including proteins, nucleic acids, lipids, and even organelles,1 are one mechanism by which α-syn pathology can be propagated.2, 3 Although the classical pathologies that define PD—the presence of Lewy bodies (LBs) and the death of dopaminergic...

Aug 10, 2023 | onlinelibrary.wiley.com | Zhenwei Yu |Ying Yang |Robin Chan |Tessandra Stewart

1 INTRODUCTION Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy body (DLB) are broadly defined as synucleinopathies.1 PD, the most common type of synucleinopathy, is clinically characterized by motor symptoms resulting largely from the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc).2, 3 Synucleinopathies share a common pathological characteristic by the accumulation of α-synuclein (α-syn) aggregates in the brain, a process...