Thangavel Alphonse

Feb 27, 2024 | zenodo.org | Al Ali |Le Voyer |Paul Bastard |Thangavel Alphonse |Al Qureshah |Seyed Mohammad | +4 more

We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–a T cell receptor (pre-TCRa) expression. Low circulating naive ab T cell counts at birth persisted over time, with normal memory ab and high gd T cell counts. Their TCRa repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue ab T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity.

Mar 14, 2023 | frontiersin.org | Thangavel Alphonse |Tarunveer S. Ahluwalia |Sulev Kõks |Edith Hofer

1 IntroductionObesity has now become a global epidemic with an alarmingly increasing rate of incidence (1). The World Health Organization (WHO) reports that the worldwide prevalence of obesity nearly tripled between 1975 and 2016 and is expected to double in the next 25 years (2, 3). Different ethnicities exhibit different rates of obesity. This is evident in the different rates of obesity in ethnicities such as those of Southeast Asians, Arabs, and South Asians.