Tharika Thambidurai

Apr 24, 2024 | biorxiv.org | Tilo Thottakara |Arun Padmanabhan |Talha Tanriverdi |Tharika Thambidurai

AbstractHypertrophic cardiomyopathy (HCM) is associated with phenotypic variability. To gain insights into transcriptional regulation of cardiac phenotype, single-nucleus linked RNA-/ATAC-seq was performed in 5-week-old control mouse-hearts (WT) and two HCM-models (R92W-TnT, R403Q-MyHC) that exhibit differences in heart size/function and fibrosis; mutant data was compared to WT.