Theo K. Bammler

Feb 6, 2025 | nature.com | Brennan H. Baker |Theo K. Bammler |Emily S. Barrett |Nicole R. Bush |Brent R. Collett |Daniel A. Enquobahrie | +10 more

Despite evidence linking prenatal acetaminophen (APAP) exposure and adverse neurodevelopment in humans and animals, over half of pregnant women in most populations use APAP. Prior studies could be biased by inaccurate self-reported APAP use, and the molecular mechanisms linking prenatal APAP with adverse neurodevelopment are unknown. Here we estimated associations between maternal plasma biomarkers of APAP exposure, child attention deficit hyperactivity disorder (ADHD) and placental gene expression in 307 African American mother–child pairs. Overall, detection of APAP in second trimester plasma was associated with higher odds for child ADHD diagnosis (odds ratio of 3.15 (95% confidence interval 1.20 to 8.29)). Prenatal APAP exposure and ADHD were associated with placental upregulation of immune system pathways in females and downregulation of oxidative phosphorylation in both sexes. In females only, prenatal APAP was associated with 5.22% higher odds (0.0456–13.1%) of ADHD statistically, mediated through increased immunoglobulin heavy constant gamma 1 (IGHG1) expression. These results highlight placental molecular mechanisms that may underlie developmental toxicity of prenatal APAP exposure. In this study, the authors report that maternal plasma biomarkers of acetaminophen exposure during pregnancy were associated with an increased risk of a diagnosis of child attention deficit hyperactivity disorder. The findings suggest that acetaminophen exposure impacts immune pathways and oxidative phosphorylation, potentially mediating neurodevelopmental risks.

Jan 17, 2025 | dx.doi.org | Filip Stefanovic |Lauren Brown |James MacDonald |James Macdonald |Theo K. Bammler

AbstractClick to copy section linkSection link copied!Remote research studies are an invaluable tool for reaching populations with limited access to large medical centers or universities. To expand the remote study toolkit, we previously developed homeRNA, which allows for at-home self-collection and stabilization of blood and demonstrated the feasibility of using homeRNA in high temperature climates.

Jan 17, 2025 | pubs.acs.org | Filip Stefanovic |Lauren Brown |James MacDonald |James Macdonald |Theo K. Bammler

Aug 25, 2024 | biorxiv.org | Lauren Brown |James MacDonald |James Macdonald |Theo K. Bammler |Filip Stefanovic

AbstractRemote research studies are an invaluable tool for reaching populations in geographical regions with limited access to large medical centers or universities. To expand the remote study toolkit, we have previously developed homeRNA, which allows for at-home self-collection and stabilization of blood and demonstrated the feasibility of using homeRNA in high temperature climates.

May 14, 2024 | dmd.aspetjournals.org | Christopher M. Arian |James MacDonald |James Macdonald |Theo K. Bammler |Eimear O Mahony

AbstractTo further the development of an in vitro model which faithfully recapitulates drug disposition of orally administered drugs, we investigated the utility of human enteroid monolayers to simultaneously assess intestinal drug absorption and first-pass metabolism processes.