Theo Rein

Jul 25, 2024 | digitalcommons.library.tmc.edu | Gabriel R. Fries |Valeria A. Saldana |Johannes Finnstein |Theo Rein

AbstractMajor depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression.

May 21, 2024 | nature.com | Theo Rein

In a study recently published in Nature, Cathomas et al.1 report that social stress in mice increases the levels of matrix metalloprotease (MMP)8 in circulating immune cells, thereby altering extracellular space (ECS) and neuronal activity, and ultimately social behavior in susceptible animals. Behavioral deficits resembled those from major depressive disorder (MDD) raising the prospect of MMP8 as a new druggable target in tailored treatments.