Thiloma Liyanage

Apr 10, 2024 | biorxiv.org | Nicole Lee |Serena Tijoriwalla |Thiloma Liyanage |Thilina U.B. Herath

AbstractThe food-borne pathogen Listeria monocytogenes uses actin-based motility to generate plasma membrane protrusions that mediate the spread of bacteria between host cells. In polarized epithelial cells, efficient protrusion formation by Listeria requires the secreted bacterial protein InlC, which binds to a carboxyl-terminal Src Homology 3 (SH3) domain in the human scaffolding protein Tuba.