Thomas A. Hilimire

Mar 28, 2024 | jci.org | Jing Li |Thomas A. Hilimire |Liu Yueying |Lili Wang

ResearchOncologyTherapeuticsOpen Access | 10.1172/JCI176709 J Clin Invest. https://doi.org/10.1172/JCI176709. Copyright © 2024, Li et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Aug 11, 2023 | biorxiv.org | Jing Li |Thomas A. Hilimire |Yueying Liu |Lili Wang

AbstractCastration-resistant prostate cancer (CRPC) remains incurable due to its high plasticity. We found that Mediator kinases CDK8 and CDK19, pleiotropic regulators of transcriptional reprogramming, are differentially affected by androgen, which downregulates CDK8 and upregulates CDK19. Accordingly, expression of CDK8 decreases while CDK19 increases during prostate carcinogenesis, but both CDK19 and CDK8 are upregulated in metastatic CRPC.