Thomas Ahearn

Sep 25, 2023 | nature.com | Haoyu Zhang |Jingning Zhang |Thomas Ahearn |Zhi Yu |TONY CHEN |Montserrat Garcia-Closas | +1 more

AbstractPolygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal performance in non-European populations raise concerns about clinical applications and health inequities. We developed CT-SLEB, a powerful and scalable method to calculate PRSs, using ancestry-specific genome-wide association study summary statistics from multiancestry training samples, integrating clumping and thresholding, empirical Bayes and superlearning.