Tian Mi

Oct 10, 2024 | science.org | Dimitri Fabrèges |Stephanie Hampton |Xin Lan |Tian Mi

Editor’s summaryT cell immunotherapies have been successful in treating some intractable cancers, but there are limitations caused by the inability of T cells to persist after prolonged stimulation. Kang et al. undertook a reverse-translation approach to investigate the molecular mechanisms regulating the durability of T cell responsiveness to checkpoint blockade immunotherapy (see the Perspective by Tsui and Kallies).