Tian Tian

Nov 18, 2024 | biorxiv.org | Liyun Huo |Qin Qin |Tian Tian |Xing Zhang

AbstractSince the outbreak of the COVID-19 pandemic in 2019, antibody-based therapies have played a key role in combating the virus. In addition to conventional antibodies, single-domain heavy-chain antibodies (nanobodies) derived from camelids have emerged as promising therapeutic candidates due to their small molecular weight, high stability, and strong binding affinity.

Nov 16, 2024 | mdpi.com | Mo Li |Tian Tian |Tsung-Yu Yang

1. IntroductionIn internal combustion engines, oil control rings play a crucial role in controlling the oil supply and significantly impacting lubricating oil consumption. TPOCRs have been widely adopted in modern engines due to their efficient oil control and reduced oil consumption. Although the use of TPOCRs has become prevalent, research on this topic remains notably lacking. The oil control ring shown in Figure 1 consists of three components, the upper rail, expander, and lower rail.

Nov 15, 2024 | genomemedicine.biomedcentral.com | Tongpeng Xu |Tian Tian |Chen Wang |Xiaofeng Chen |Xiangrong Zuo |Hanyu Zhou | +9 more

This was a researcher-initiated, single-arm, open-label, single-center, first-in-human clinical trial (ChiCTR2100046544) designed to evaluate the safety and efficacy of KT032 in patients with mesothelin-expressing advanced solid tumors between August 2021 and February 2024, at the First Affiliated Hospital of Nanjing Medical University. Tumor biopsies were evaluated for mesothelin (MSLN) expression at enrolment, followed by leukapheresis and KT032 manufacture.

Oct 30, 2024 | biorxiv.org | Liyun Huo |Tian Tian |Yanqin Xu |Qin Qin

AbstractIn recent years, single-domain heavy chain antibodies (nanobodies), with only one-tenth the molecular weight of conventional antibodies, have emerged as important therapeutic proteins in the fight against SARS-CoV-2. However, the rapid mutation of the virus often renders existing nanobodies ineffective, underscoring the need to develop nanobodies that specifically target new variants.

Oct 16, 2024 | mdpi.com | Yi Hong |Zhuang Wen |Guang Qiao |Tian Tian

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