Tianxi Cai

May 29, 2024 | onlinelibrary.wiley.com | Layla Parast |Lu Tian |Tianxi Cai

Supporting Information Filename Description sim10122-sup-0001-Supinfo.zipZip archive, 50.9 KB Data S1: Supporting Information. REFERENCES 1. Are surrogate markers adequate to assess cardiovascular disease drugs? Jama. 1999; 282(8): 790-795. 2 FDA. Table of Surrogate Endpoints That Were the Basis of Drug Approval or Licensure. https://www.fda.gov/drugs/development-resources/table-surrogate-endpoints-were-basis-drug-approval-or-licensure 2022. 3 Geary.

Oct 31, 2023 | drc.bmj.com | Layla Parast |Lu Tian |Tianxi Cai |Latha Palaniappan

DiscussionThe results demonstrate that, of the five examined surrogate markers, fasting glucose and HOMA-IR explained the largest proportions of the treatment effect when comparing lifestyle intervention with placebo. The TyG index and HbA1c were the weakest surrogate markers in terms of the proportion of the treatment effect that could be explained.

Apr 13, 2023 | nature.com | Harrison Zhang |Jacqueline P. Honerlaw |Sehi L’Yi |Yuk-Lam Ho |Vidul Ayakulangara Panickan |Katherine P Liao | +4 more

The value of large-scale, real-world data — from electronic health records (EHRs), for example — has been used to establish vaccine efficacy, to elucidate the genetic etiologies of diseases, and to advance epidemiological research1,2,3. Real-world data also have the potential to capture the wide spectrum of clinical features attributed to post-acute sequalae of SARS-CoV-2, also called long COVID, in diverse patient populations4.