Tiddo J. Mooibroek

Oct 10, 2023 | onlinelibrary.wiley.com | Federica Balduzzi |Patrick Stewart |Soumen K. Samanta |Tiddo J. Mooibroek

A major theme of modern supramolecular chemistry is the development of synthetic receptors that bind complementary guests in aqueous environments with very high affinities.1 Inspiration is taken from the natural binding pairs avidin-biotin and streptavidin-biotin, for which association constants of the order of 1015 m−1 have been measured.2 In addition to the theoretical interest, and the challenge, posed by such numbers, the (strept)avidin-biotin pairs have valuable applications in...