Tiffany Amariuta

Nov 30, 2023 | nature.com | Aparna Nathan |Saori Sakaue |Alkes L Price |Tiffany Amariuta

AbstractIn autoimmune diseases such as rheumatoid arthritis, the immune system attacks the body’s own cells. Developing a precise understanding of the cell states where noncoding autoimmune risk variants impart causal mechanisms is critical to developing curative therapies.

Oct 19, 2023 | nature.com | Tiffany Amariuta

The mechanisms of many disease-associated variants are uncertain because of limited power to detect their modest effects on gene expression. This study finds that natural selection leads to preferential detection of disease-associated versus expression-associated variants. Mostafavi et al.4 identified 22,119 lead variants from GWAS across 44 UK Biobank phenotypes and 118,996 lead variants from eQTL analysis of protein-coding genes across 38 tissues from the GTEx and eQTLGen studies5,6.

Aug 14, 2023 | nature.com | Tiffany Amariuta |Alkes L Price

AbstractIntegrative analyses of genome-wide association studies and gene expression data have implicated many disease-critical tissues. However, co-regulation of genetic effects on gene expression across tissues impedes distinguishing biologically causal tissues from tagging tissues.