Tiffany Yesavage

Denver

Science writer at Freelance

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Articles

CAR T-Cell Therapy: New Advances Move On Past Setbacks

3 weeks ago | genengnews.com | Tiffany Yesavage

Home Topics Cancer CAR T-Cell Therapy: New Advances Move On Past Setbacks Illustration showing chimeric antigen receptor (CAR) T cells attacking kidney cancer cells. [Nemes Laszlo / Science Photo Library / Getty Images] Illustration showing chimeric antigen receptor (CAR) T cells attacking kidney cancer cells.
Biology Has Evolved. Regulation Hasn’t. Here’s the Fallout

1 month ago | synbiobeta.com | Tiffany Yesavage

In the United States, synthetic biology products are overseen by a patchwork of federal agencies, often guided by outdated and difficult-to-interpret regulations. Consequently, many innovators struggle to navigate this confusing landscape. SynBioBeta recently spoke with three biotech regulation experts, gathering their insights and practical advice to help innovators steer clear of regulatory roadblocks.
TILs’ Tomorrow Bringing More Cancers Under Immune Control

1 month ago | genengnews.com | Tiffany Yesavage

Tumor-infiltrating lymphocytes (TILs) are a grouping of mostly T cells that enter tumors and elicit an initial immune response. But as Jason Bock, PhD, co-founder and CEO of CTMC, explains, “These cells have been fighting against the tumor, but the balance has shifted, and the tumor has gained the upper hand.” He notes that traditional TIL therapy typically involves extracting the TILs from each patient’s tumor, expanding and reinvigorating them, and then reinfusing them into the patient.
Cancer Immunotherapy: From Nineteenth-Century Beginnings to Modern Breakthroughs

Feb 3, 2025 | genengnews.com | Tiffany Yesavage

Home Topics Cancer Cancer Immunotherapy: From Nineteenth-Century Beginnings to Modern Breakthroughs Hopewell delivers mRNA via lipid nanoparticles that enter the cell through endocytosis. The nanoparticle is then engulfed by the cell membrane, releasing therapeutic mRNA into the cytoplasm. [KATERYNA KON/ Science Photo Library/ Getty Images] Hopewell delivers mRNA via lipid nanoparticles that enter the cell through endocytosis.
AI in Drug Design: From Hype to Real-World Results

Oct 2, 2024 | genengnews.com | Tiffany Yesavage

Home Topics Artificial Intelligence AI in Drug Design: From Hype to Real-World Results Credit: Marco Marca/ iStock / Getty Images Plus Share Facebook Twitter Linkedin ReddIt Email Experts have been raising concerns about “AI washing.” One of these experts, futurist Bernard Marr, has said that AI washing “involves exaggerating the capabilities of a product or service that is sold as ‘AI’ in order to make it look more sophisticated, innovative, or intelligent than it actually is.” This...
Cancer Vaccines: New Targeting Strategies, Brighter Prospects

Jul 31, 2024 | genengnews.com | Tiffany Yesavage

Home Topics Infectious Diseases Cancer Vaccines: New Targeting Strategies, Brighter Prospects Credit: Marcin Klapczynski/iStock/Getty Images Credit: Marcin Klapczynski/iStock/Getty Images The basic idea behind cancer vaccines has been around since the 1890s, when physician William Coley administered a vaccine of sorts, a preparation of bacterial toxins, to cancer patients.
Assessing Cellular PARylation: Convenient ELISA-Based Methods

Jun 27, 2024 | biocompare.com | Tiffany Yesavage

Post-translational modifications—including phosphorylation, methylation, acetylation, ubiquitylation, and glycosylation—are covalent processes that alter the function of proteins.1 PARylation is another post-translational modification of emerging interest associated with inflammation, metabolism, and cell death.1 Although PARylation often occurs at very low levels, convenient commercial assays allow researchers to measure this phenomenon in cells.
Growth Factors for Cell Cultures: Tips and Best Practices

Mar 7, 2024 | biocompare.com | Tiffany Yesavage

Growth factors—including cytokines like IL-6, TNF-α, IL-15, IL-7, and INF-γ—are chemical messengers that mediate intracellular communication and regulate cellular functions.1 Although many companies offer a wide array of high-quality cytokines for the in vitro culture of immune cells, stem cells, organoids, and other cell types, finding the right growth factors can be challenging. Which growth factors to useRelevant scientific literature is always a great place to start.
Protease and Phosphatase Inhibitors: Tips for the Lab

Nov 13, 2023 | biocompare.com | Tiffany Yesavage

With so many brands of protease and phosphatase inhibitors, it can be difficult to know which ones best suit your experimental needs. This article will provide tips about how to choose inhibitors and how to use them in the lab. What are protease and phosphatase inhibitors? Proteases and phosphatases are essential enzymes for a variety of biochemical pathways. Proteases break proteins into smaller polypeptides or amino acids during the process of proteolysis.