Timothy W. Secomb

2 months ago | onlinelibrary.wiley.com | Sara Djurich |Grace Lee |Timothy W. Secomb

Objective Local control of blood flow depends on signaling to arterioles via upstream conducted responses. Here, the objective is to examine how electrical properties of gap junctions between endothelial cells (EC) affect the spread of conducted responses in microvascular networks of the brain cortex, using a theoretical model based on EC electrophysiology.

Aug 31, 2023 | physoc.onlinelibrary.wiley.com | Kevin Webb |Michael Joyner |Chad Wiggins |Timothy W. Secomb

1 INTRODUCTION Human activity is drastically constrained at extreme altitudes due to low environmental oxygen availability. Few humans can reach the highest elevation on earth, the summit of Mt. Everest (~8850 m), without supplemental oxygen, and those who do are limited to such a degree that a slow uphill walk approaches the maximum capacity for oxygen uptake and utilization (V̇O2max).