Toby Eyre

1 month ago | ascopubs.org | Toby Eyre |Anita Kumar |Steven Le Gouill

Mantle cell lymphoma (MCL) represents a relatively uncommon, heterogeneous lymphoma associated with limited overall survival. Targeting of the B-cell receptor pathway in relapsed disease with covalent Bruton tyrosine kinase (cBTK) inhibition has been demonstrated to be highly effective with cBTK inhibitor monotherapy, an established standard of care in relapsed MCL.

Aug 19, 2024 | onlinelibrary.wiley.com | Jaimal Kothari |Toby Eyre |Ali Rismani

INTRODUCTION Waldenström's Macroglobulinaemia (WM) is a low-grade B-cell non-Hodgkin lymphoma, characterised by the presence of a monoclonal immunoglobulin M (IgM) and lymphoplasmacytic lymphoma. It is typically a disease of the elderly with a median age at presentation of over 70 years and an incidence of 0.57 per 100 000 person-years.1, 2 MYD88 L265P activating mutations are seen in over 90% of WM patients, with CXCR4 mutations in approximately 30%.

Nov 13, 2023 | onlinelibrary.wiley.com | Toby Eyre |Sally F. Barrington |Renata Walewska

METHODOLOGY These guidelines were compiled according to the BSH process: https://b-s-h.org.uk/media/16732/bsh-guidance-development-process-dec-5-18.pdf. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org. Recommendations are based on a review of the literature using Medline/Pubmed.

Oct 25, 2023 | onlinelibrary.wiley.com | Toby Eyre |Mark Bishton |Rory McCulloch |Maeve O'Reilly

SCOPE The objective of this guideline is to provide healthcare professionals with clear guidance on the diagnosis and management of patients with mantle cell lymphoma. METHODOLOGY This Guideline was compiled according to the BSH process at https://b-s-h.org.uk/media/16732/bsh-guidance-development-process-dec-5-18.pdf and represents best practice in both teaching and district hospitals in the United Kingdom.