Tomasz P. Jurkowski

2 months ago | pubs.acs.org | Carlos C. Smith-Díaz |Andrew Das |Tomasz P. Jurkowski |Timothy A. Hore

SignificanceClick to copy section linkSection link copied!The biochemical flexibility of ascorbate contributes to its capacity to support 2-oxoglutarate-dependent dioxygenase activity, in preference to other antioxidants. As a highly efficient radical scavenger, Fe(III) reductant and chelating agent, ascorbate can prevent enzyme inactivation by the highly oxidizing reaction cycle intermediates and help stabilize the iron in the active site.

2 months ago | dx.doi.org | Carlos C. Smith-Díaz |Andrew Das |Tomasz P. Jurkowski |Timothy A. Hore

SignificanceClick to copy section linkSection link copied!The biochemical flexibility of ascorbate contributes to its capacity to support 2-oxoglutarate-dependent dioxygenase activity, in preference to other antioxidants. As a highly efficient radical scavenger, Fe(III) reductant and chelating agent, ascorbate can prevent enzyme inactivation by the highly oxidizing reaction cycle intermediates and help stabilize the iron in the active site.