Tongling Huang

May 4, 2024 | nature.com | Tongling Huang |Zhaocheng Lu |Zihui Wang |Lixin Cheng |Lu Gao |Jun Gao | +4 more

AbstractExcessive bone marrow adipocytes (BMAds) accumulation often occurs under diverse pathophysiological conditions associated with bone deterioration. Estrogen-related receptor α (ESRRA) is a key regulator responding to metabolic stress. Here, we show that adipocyte-specific ESRRA deficiency preserves osteogenesis and vascular formation in adipocyte-rich bone marrow upon estrogen deficiency or obesity.

Aug 14, 2023 | biorxiv.org | Zihui Wang |Lixin Cheng |Tongling Huang |Zhaocheng Lu

AbstractEctopic bone marrow adipocytes (BMAds) accumulation occurring under diverse pathophysiological conditions leads to bone deterioration. Estrogen-related receptor α (ESRRA) is a key regulator responding to metabolic stress. Here, we show that adipocyte-specific ESRRA deficiency rescues osteogenesis and vascular formation in adipocyte-rich bone marrow due to estrogen deficiency or obesity.