Torben Rogge

Aug 11, 2024 | nature.com | Torben Rogge |K. N. Houk

AbstractDirect arene C−H functionalization via nucleophilic aromatic substitution remains a challenging task. Here we report an iridium nitrenoid-catalysed arene C−H functionalization strategy, making use of readily available aryl azides as electrophiles to react with different nucleophilic reaction partners.

May 31, 2023 | nature.com | Shuo-Qing Zhang |Torben Rogge |Xin Hong

AbstractChallenging enantio- and diastereoselective cobalt-catalyzed C–H alkylation has been realized by an innovative data-driven knowledge transfer strategy. Harnessing the statistics of a related transformation as the knowledge source, the designed machine learning (ML) model took advantage of delta learning and enabled accurate and extrapolative enantioselectivity predictions.