Toru Suzuki

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Articles

A program of successive gene expression in mouse one-cell embryos

Jan 31, 2023 | cell.com | Maki Asami |Brian Lam |Martin Hoffmann |Toru Suzuki

Highlights•A gene expression program, iEGA, initiates within 4 h of mouse fertilization•Upregulated genes are normatively spliced, protein coded, and soon downregulated•iEGA genes predict cancer-associated pathways and transcription regulators•Inhibiting predicted transcription regulators acutely disrupts iEGA and developmentSummaryAt the moment of union in fertilization, sperm and oocyte are transcriptionally silent.

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