Trevor Bedford

Sep 13, 2024 | medrxiv.org | John Huddleston |Trevor Bedford

The authors have declared no competing interest. This work was funded by NIAID R01 AI165821-01. TB is a Howard Hughes Medical Institute Investigator. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Aug 29, 2024 | biorxiv.org | Sravani Nanduri |Allison Black |Trevor Bedford |John Huddleston

AbstractPublic health researchers and practitioners commonly infer phylogenies from viral genome sequences to understand transmission dynamics and identify clusters of genetically-related samples. However, viruses that reassort or recombine violate phylogenetic assumptions and require more sophisticated methods. Even when phylogenies are appropriate, they can be unnecessary or difficult to interpret without specialty knowledge.

Feb 8, 2024 | biorxiv.org | Allison Black |Trevor Bedford |John Huddleston |Sravani Nanduri

AbstractPublic health researchers and practitioners commonly infer phylogenies from viral genome sequences to understand transmission dynamics and identify clusters of genetically-related samples. However, viruses that reassort or recombine violate phylogenetic assumptions and require more sophisticated methods. Even when phylogenies are appropriate, they can be unnecessary or difficult to interpret without specialty knowledge.

Oct 24, 2023 | cell.com | Kathryn Kistler |Trevor Bedford

Highlights•Ongoing adaptive evolution in human endemic viruses is largely in surface proteins•Immune evasion drives continuous adaptive evolution in many endemic human viruses•Antigenic evolution occurs in several viral families•SARS-CoV-2 is accumulating protein-coding changes faster than other endemic virusesSummaryThrough antigenic evolution, viruses such as seasonal influenza evade recognition by neutralizing antibodies.

May 22, 2023 | biorxiv.org | Kathryn Kistler |Trevor Bedford

AbstractThrough antigenic evolution, viruses like seasonal influenza evade recognition by neutralizing antibodies elicited by previous infection or vaccination. This means that a person with antibodies well-tuned to an initial infection will not be protected against the same virus years later and that vaccine-mediated protection will decay. It is not fully understood which of the many endemic human viruses evolve in this fashion.