
Tsuyoshi Takiuchi
Articles
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2 months ago |
nature.com | Moto Yaga |Kentaro Fukushima |Hirohisa Nakamae |Satoshi Yoshihara |Haruhiko Kishima |Tsuyoshi Takiuchi | +5 more
AbstractAcute myeloid leukemia (AML)-specific target antigens are difficult to identify. Here we demonstrate that HLA-DRB1 can serve as a leukemia-specific target of chimeric antigen receptor (CAR) T cells in patients with AML after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified KG2032 as a monoclonal antibody specifically bound to AML cells in about half of patients, but not to normal leukocytes other than B lymphocytes.
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