Tsuyoshi Takiuchi

Mar 24, 2025 | nature.com | Moto Yaga |Kentaro Fukushima |Hirohisa Nakamae |Satoshi Yoshihara |Haruhiko Kishima |Tsuyoshi Takiuchi | +5 more

AbstractAcute myeloid leukemia (AML)-specific target antigens are difficult to identify. Here we demonstrate that HLA-DRB1 can serve as a leukemia-specific target of chimeric antigen receptor (CAR) T cells in patients with AML after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified KG2032 as a monoclonal antibody specifically bound to AML cells in about half of patients, but not to normal leukocytes other than B lymphocytes.