Ty Hergenreder

Apr 20, 2023 | journals.plos.org | Hao Liu |Ty Hergenreder |René N. Caballero-Florán

Loading metrics Open Access Peer-reviewedResearch Article AbstractDown syndrome (DS) is caused by the trisomy of human chromosome 21 (HSA21). A major challenge in DS research is to identify the HSA21 genes that cause specific symptoms. Down syndrome cell adhesion molecule (DSCAM) is encoded by a HSA21 gene. Previous studies have shown that the protein level of the Drosophila homolog of DSCAM determines the size of presynaptic terminals.