Tyler L Dangerfield

Apr 18, 2024 | nature.com | Evan Schwartz |Mohd Neyaz Ahsan |Luis A. Macias |Caitlyn L. McCafferty |Tyler L Dangerfield |Jada Walker | +4 more

AbstractCRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction1,2,3,4,5. Target RNA cleavage at regular intervals is characteristic of type III effector complexes6,7,8. Here, we determine the structures of the Synechocystis type III-Dv complex, an apparent evolutionary intermediate from multi-protein to single-protein type III effectors9,10, in pre- and post-cleavage states.