Tyler Starr

Jul 24, 2024 | biorxiv.org | Ashley Taylor |Tyler Starr

AbstractDeep mutational scanning experiments aid in the surveillance and forecasting of viral evolution by providing prospective measurements of mutational effects on viral traits, but epistatic shifts in the impacts of mutations can hinder viral forecasting when measurements were made in outdated strain backgrounds.

Dec 29, 2023 | journals.plos.org | Ashley Taylor |Tyler Starr |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Taylor AL, Starr TN (2023) Deep mutational scans of XBB.1.5 and BQ.1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution. PLoS Pathog 19(12): e1011901. https://doi.org/10.1371/journal.ppat.1011901Editor: Sergei L. Kosakovsky Pond, Temple University, UNITED STATESReceived: September 19, 2023; Accepted: December 14, 2023; Published: December 29, 2023Copyright: © 2023 Taylor, Starr.

Sep 12, 2023 | biorxiv.org | Ashley Taylor |Tyler Starr

AbstractSubstitutions that fix between SARS-CoV-2 variants can transform the mutational landscape of future evolution via epistasis. For example, large epistatic shifts in mutational effects caused by N501Y underlied the original emergence of Omicron variants, but whether such large epistatic saltations continue to define ongoing SARS-CoV-2 evolution remains unclear.