Utsav Mukherjee

May 7, 2024 | biorxiv.org | Satya Murthy Tadinada |Utsav Mukherjee |Emily Walsh |Ted Abel

AbstractcAMP signaling is critical for memory consolidation and certain of forms long-term potentiation (LTP). Phosphodiesterases (PDEs), enzymes that degrade the second messenger cAMP and cGMP, are highly conserved during evolution and represent a unique set of drug targets, given the involvement of these enzymes in several pathophysiological states including brain disorders.