Vakul Mohanty

Aug 22, 2024 | digitalcommons.library.tmc.edu | Yuefan Huang |Vakul Mohanty |Merve Dede |Kyle P. Tsai

AbstractCells often alter metabolic strategies under nutrient-deprived conditions to support their survival and growth. Characterizing metabolic reprogramming in the tumor microenvironment (TME) is of emerging importance in cancer research and patient care. However, recent technologies only measure a subset of metabolites and cannot provide in situ measurements.

Feb 5, 2024 | nature.com | Vakul Mohanty

Perturbation of metabolic processes in cancer cells is often associated with patient outcome, drug resistance and vulnerability to specific therapies. Understanding the metabolic alterations present in cancer is fundamental to the development of novel therapeutics. Although recent advances in high-throughput metabolomics have made the unbiased study of cancer metabolism possible, considerable challenges remain in acquiring and analysing these data.

Jan 18, 2024 | nature.com | Hind Rafei |May Daher |Vakul Mohanty |Merve Dede |Peter F Thall |Roland Bassett | +6 more

AbstractThere is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord blood-derived natural killer (NK) cells expressing anti-CD19 chimeric antigen receptor and interleukin-15 (CAR19/IL-15) in 37 patients with CD19+ B cell malignancies. The primary objectives were safety and efficacy, defined as day 30 overall response (OR).