Val A. Fajardo

Jul 18, 2024 | nature.com | Jessica Braun |Val A. Fajardo

AbstractSpending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for bringing Ca2+ from the cytosol into its storage site, the sarcoplasmic reticulum (SR), at the expense of ATP.

Jan 30, 2024 | biorxiv.org | Jessica Braun |Val A. Fajardo

AbstractSpending time in a microgravity environment is known to cause significant skeletal muscle atrophy and weakness via muscle unloading, which can be partly attributed to Ca2+ dysregulation. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump is responsible for bringing Ca2+ from the cytosol into its storage site, the sarcoplasmic reticulum (SR), at the expense of ATP.

Dec 12, 2023 | nature.com | Kevin Li |Ryan Scott |Joel Steele |Samuel Demharter |Adrienne Hoarfrost |Jessica Braun | +1 more

AbstractThe adverse effects of microgravity exposure on mammalian physiology during spaceflight necessitate a deep understanding of the underlying mechanisms to develop effective countermeasures. One such concern is muscle atrophy, which is partly attributed to the dysregulation of calcium levels due to abnormalities in SERCA pump functioning.