Vara Prasad Josyula

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Targeting an Olfactory Receptor Mitigates High Residual Platelet Reactivity and Arterial Thrombosis Through Actin Cytoskeleton Depolymerization

Oct 1, 2024 | biorxiv.org | Anu Aggarwal |Nancy Wang |Moua Yang |Vara Prasad Josyula

AbstractBackground: Despite antiplatelet therapy, some patients remain at high risk for ischemic events due to medication non-responsiveness or High Residual Platelet Reactivity (HRPR). Our goal was to target an orphan G-Protein-Coupled Receptor (GPCR) on platelets belonging to the olfactory receptor family as a new antithrombotic strategy.

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