Varshini Mohan

Aug 16, 2023 | biorxiv.org | Aishwarya Kulkarni |Varshini Mohan |Tracy Tang |Murray Manning

AbstractThe Hippo tumour suppressor pathway controls transcription by regulating nuclear abundance of YAP and TAZ, which activate transcription with the TEAD1-TEAD4 DNA-binding proteins. Recently, several small-molecule inhibitors of YAP and TEADs have been reported, with some now entering clinical trials for different cancers. Here, we investigated the cellular response to TEAD palmitoylation inhibitors, using a combination of genomic and genetic strategies.